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Department seminar 06/06 2pm: Wireless Optoelectronic Microsystems for Combined Optogenetics and Opto-Electrophysiology

Professor Benoit Gosselin

Université Laval

Wireless Optoelectronic Microsystems
for Combined Optogenetics and Opto-Electrophysiology

Date: Thursday June 6th 14:00 – 15:00

Location: LAS 3033

Abstract:

Optogenetics is a neural stimulation technique that allows using light to control and monitor individual neurons in living tissue. This ground-breaking approach is highly sought after to carry out various neuroscience experiments in freely-behaving rodents, especially mice, which serve as common disease models. As a result, the development of advanced optogenetic hardware combining multiple technologies, such as bioMEMS, optics, microelectronics, and wireless technology has become a source of significant interest. After a review of the state of the art, this tutorial will present advanced systems for enabling combined optogenetics and multichannel electrophysiology in freely moving transgenic rodents. First, we will present different wireless headstage systems developed with commercial off-the-shelf components. We will show strategies to perform spike detection and data compression in real-time over 32 neural recording channels, and we will present circuits for driving several photo-stimulation LED in parallel. Then, we will present CMOS circuits for parallel photostimulation and multichannel neural recording using miniaturized integrated systems. We will cover the design of CMOS LED driver circuits for embedded LEDs, and neural amplifiers for collecting either action potentials and/or local field potentials with high-quality. We will introduce low-power programmable sigma-delta analog-to-digital converter topologies working at low oversampling ratios to address the flexibility needed in this application with respect to different noise versus power consumption tradeoff in various experimental settings. Finally, we will present different experimental results obtained in-vivo after performing simultaneous photo-stimulation and neural recording in live transgenic rodents with these systems.

Speaker:

Benoit Gosselin (S’02–M’08) obtained the Ph.D. degree in Electrical Eng. from École Polytechnique de Montréal in 2009, and he was an NSERC Postdoctoral Fellow at the Georgia Institute of Technology in 2010. He is currently a Full Professor at the Depart. of ECE at Université Laval, where he holds the Canada Research Chair in Smart Biomedical Microsystems. His research interests include wireless microsystems for brain computer interfaces, analog/mixed-mode and RF integrated circuits for neural engineering, interface circuits of implantable sensors/actuators and point-of-care diagnostic microsystems for personalized healthcare.

Dr Gosselin is an Associate Editor of the IEEE Transactions on Biomedical Circuits and Systems and he is Chair and Founder of the IEEE CAS/EMB Quebec Chapter (2015 Best New Chapter Award). He served on the committees of several int’l conferences such as IEEE BIOCAS, IEEE NEWCAS, IEEE EMBC, IEEE LSC and IEEE ISCAS. Currently he is Chair of the Technical Program Committee of the IEEE EMBC 2020. His significant contribution to biomedical microsystems research led to the commercialization of the first wireless microelectronic platform for optogenetics and electrophysiology with live animals by Doric Lenses Inc. He has received several awards, including the Mitacs Award for Outstanding Innovation and the NSERC Brockhouse Canada Prize for Interdisciplinary Research in Science and Engineering.